AVINEW

                                                          AVINEW^® FROZEN 

South Africa Reg. No. G2765     Act 36/1947

Namibia Reg. No. V12/24.3/1090 (NS0)

 

Newcastle disease is a controlled disease in terms of the Animal Disease Act (Act 35/1984).  In terms of the Act: Any occurrence of Newcastle disease has to be reported immediately to the local State Veterinarian.

 

FROZEN LIVE NEWCASTLE DISEASE STRAIN VG/GA-AVINEW VACCINE

 

INDICATION

For the immunisation of fowls to prevent Newcastle Disease.

 

COMPOSITION                                                

Each dose of vaccine contains:                               

Newcastle Disease Virus VG/GA-AVINEW Strain at least 10^5.5 EID ₅₀.*

*EID₅₀: 50% egg infective dose

Corresponds to at least 15 PD₉₀ (protective dose 90%)

 

STORAGE

Store in liquid nitrogen. The level of liquid nitrogen should be checked weekly and replenished as necessary.

 

WARNINGS

·         Do not slaughter fowls for human consumption within 21 days after vaccination.

·         Vaccinate healthy fowls only.

·         Keep out of reach of children, uninformed persons and animals.

·         Do not administer simultaneously with or within 7 days after the administration of any other live vaccine.

·         Vaccinate all susceptible fowls on the farm at the same time, or if this is not possible, prevent the spread of vaccine virus from the vaccinated to the unvaccinated fowls by suitable management procedures.

·         Do not keep partially used containers for future use and destroy any thawed vaccine and empty vaccine containers after vaccination, by for instance burning.

·         Keep liquid nitrogen containers away from chick houses and air intakes of incubators.

·         Liquid nitrogen containers and vaccines frozen in liquid nitrogen should be handled by properly trained personnel.

·         Do not inhale liquid nitrogen vapours. If drowsiness occurs, fresh air should be obtained immediately. Ventilate the whole area. Artificial respiration should be applied if breathing difficulty occurs. Medical help should be sought if breathing difficulties persist, or if loss of consciousness occurs.

·         Do not thaw ampoules in hot or cold water.

·         Frozen ampoules have been known to explode on sudden temperature change.

·         Use according to the number of doses indicated on the vial.

·         Although this vaccine has been extensively tested under a large variety of conditions, failure thereof may ensue for a wide range of reasons. If this is suspected, seek veterinary advice and notify the registration holder. 

 

PRECAUTIONS

·         Liquid nitrogen – handle with care as indicated.

·         Apply usual aseptic procedures.

·         Keep ampoules in liquid nitrogen and do not thaw vaccine until ready to use.

·         Wear protective gloves, safety glasses and long sleeves to protect the skin from liquid nitrogen when removing the ampoules, handling frozen vaccine and adding liquid nitrogen to the container. The liquid nitrogen container should be stored and handled in a dry well-ventilated are.

·         When withdrawing an ampoule from the container, the palm of the gloved hand should be held away from face and body.

·         Do not refreeze thawed vaccine.

·         Avoid contamination of the eyes, hands and clothing during handling/administration of the vaccine.

·         Do not mix with any other vaccine.

·         Note to the physician or the medical care provider

Accidental contact with the eyes could lead to severe, transient conjunctivitis. Consult a physician and inform him/her that the vaccine contains live Newcastle disease.

 

DIRECTIONS FOR USE                   

Use only as directed.

Storage and preparation of the vaccine suspension must be done with care. The following procedure is recommended.

·         Wear protective gloves and spectacles during the thawing and ampoule opening operations.

·         Remove from the liquid nitrogen only those ampoules that are to be used immediately.

·         Thaw the contents of the ampoules rapidly by agitation in water at 20 – 30 °C.

·         As soon as the last ice cube has thawed, open the ampoules. Keep these at arms length in order to prevent any risk of injury should the ampoule break.

·         Dissolve the thawed vaccine in cool, clean, non-chlorinated, antiseptic- and disinfectant-free water as described below.

 

ADMINISTRATION AND DOSAGE

v  Individual vaccination (as of 1 day of age) :

·         Eye drop method (example for 1 000 doses)

Dilute the thawed vaccine solution in 40 to 60 ml of cool, clean, non-chlorinated, antiseptic and disinfectant-free water, depending on the dropper used.

Place a drop of the vaccine solution onto one of the eyes of each fowl, allow the drop to spread across the surface of the eye and do not free the fowl until a swallowing motion has been observed.

 

v  Mass vaccination

§  Aerosol-spraying (as of 1 day of age) (example for 1 000 doses)

Dilute the thawed vaccine solution (1 ml) in 300 ml of cool, clean, non-chlorinated, antiseptic and disinfectant-free water (1 to 15 days of age) or 500 ml (21 days of age) for example.  This volume should be adapted to the equipment used.

Spray the vaccine solution above the fowls using a pressure-sprayer capable of producing micro-droplets.

For proper vaccine distribution, make sure that fowls are well squeezed together during spraying and the following quarter of an hour.

         

§  Drinking water (from 5 days of age) (example for 1 000 doses)

To ensure that the fowls are thirsty, withhold the normal water supply for 1-2 hours, depending on the ambient temperature.

 

Ensure that the drinkers are thoroughly cleaned prior to use.  Do not clean with disinfectants.

 

Add the thawed vaccine to 5 to 10 litres of cool, clean, non-chlorinated, antiseptic and disinfectant-free water This volume should be adapted to the age of the fowls and sufficient for the vaccine to be consumed within the hour following distribution.

 

Skim milk powder (0,2 % or 2 grams per litre of water) should be added to the drinking water to stabilise the vaccine virus.

 

Distribute drinkers evenly throughout the house.

 

Ensure that there are enough drinkers available to allow all of the fowls access to the vaccine-medicated water.

 

Do not recommence the normal water supply until all the vaccine-medicated water has been consumed.

 

VACCINATION SCHEDULE

*        Primary vaccination:- Day old

*        Booster vaccination:- Two weeks later and thereafter every 3 to 4 months.

 

PRESENTATION

1 000, 2 000, 2 500, 5 000 and 10000 dose ampoules